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US 10,301,594 B1Granted
Synthetic membrane-receiver complexes
AssigneeRubius Therapeutics, Inc.
InventorsAvak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
Life of this patent
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Abstract
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
Claims29
An enucleated erythroid cell comprising at least 1,000 copies of an intracellular exogenous polypeptide comprising phenylalanine ammonia lyase (PAL),
- wherein the enucleated erythroid cell is made by a process comprising introducing an exogenous nucleic acid encoding the exogenous polypeptide into a nucleated erythroid cell precursor.
An enucleated erythroid cell comprising at least 1,000 copies of an intracellular exogenous polypeptide comprising phenylalanine ammonia lyase (PAL),
- wherein the exogenous polypeptide is not fused to an endogenous polypeptide, and
- wherein the enucleated erythroid cell is made by a process comprising introducing into a nucleated erythroid cell precursor an exogenous nucleic acid encoding the exogenous polypeptide.
Dependencies are inferred from the claim text.