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US 10,301,384 B2Granted
Antibodies to IL-15
AssigneeCalypso Biotech SA
InventorsAlain Vicari, Olivier Leger
Life of this patent
Estimating the term…
Abstract
The present invention relates to antibodies binding IL-15, in particular humanized antibodies. In particular, the anti-IL-15 antibodies according to the invention are able to neutralize IL-15 activity and are useful in the prevention and/or treatment of an autoimmune disease and/or inflammatory disorder, a malignancy, transplant rejection, metabolic condition and/or an infectious disease caused by parasitic, viral or bacterial pathogens.
Claims11
An isolated antibody binding IL-15 comprising:
- a) a heavy chain variable region comprising SEQ ID NO:
- 5 or any variant thereof wherein 1, 2, 3, 4, 5 or 6 amino acids selected from arginine (R) at position H3 (VH RH3), methionine (M) at position H5 (VH MH5), alanine (A) at position H6 (VH AH6), alanine (A) at position H49 (VH AH49), aspartic acid (D) at position H61 (VH DH61), serine (S) at position H62 (VH SH62), methionine (M) at position H98 (VH MH98), tryptophan (W) at position H100C (VH WH100C), and methionine (M) at position H100E (VH MH100E) are substituted by a different amino acid, and
- b) a light chain variable region comprising SEQ ID NO:
- 24 or any variant thereof wherein 1, 2, 3, or 4 amino acids selected from tyrosine (Y) at position L36 (VL YL36), leucine (L) at position L46 (VL LL46), aspartic acid (D) at position L91 (VL DL91) and serine (S) at position L92 (VL SL92) are substituted by a different amino acid,
- or an antigen-binding fragment thereof.
2 more elements
Dependencies are inferred from the claim text.