Back to results
US 10,301,311 B2Granted
Polycyclic compounds and uses thereof
AssigneeXoc Pharmaceuticals, Inc.
InventorsThomas Armer, Scott Borland, Miguel Guzman
Life of this patent
Estimating the term…
Abstract
The present invention provides novel neuromodulatory compounds and compositions thereof. The invention also relates to methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; as well as intermediates for the preparation compounds.
Claims16
A compound represented by Formula (I):
- or a salt thereof, wherein:
- represents an optional double bond;
- R1 is selected from hydrogen;
- and C1-C3 alkyl, C3-C5 cycloalkyl, C2-4 alkenyl, C3-C5 cycloalkenyl, C2-4 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
- R2 is selected from C1-C3 haloalkyl and C3 cycloalkyl, wherein C3 cycloalkyl is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
- R3 is selected from halogen, C1-C3 alkyl, C1-C3 haloalkyl, —OR10, —SR10, —N(R10)2, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, and —CN;
- R4 is absent or selected from hydrogen and OR10, wherein R4 is absent when is a double bond and R4 is selected from hydrogen and OR10 when is a single bond;
- R5 is selected from C1-C3 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN, wherein when R2 is selected from C1 haloalkyl and is a double bond, R5 is C1-C3 alkyl optionally substituted with one or more substituents independently selected from —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
- R6 is CH2CH3 where R2 is C1-C3 haloalkyl and when R2 is C3 cycloalkyl, R6 is C1-C3 alkyl substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —N(R10)2, —NO2, ═O, and —CN;
- R7 is selected from C1-C3 alkyl, C2-4 alkenyl, and C2-4 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR10, —SR10, —C(O)N(R10)2, —N(R10)2, —S(O)R10, —S(O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —NO2, ═O, ═S, ═N(R10), and —CN;
- R10 is independently selected at each occurrence from hydrogen;
- and C1-C3 alkyl optionally substituted with one or more substituents independently selected from halogen, —OH, —OCH3, —CF3, —SH, —NH2, —NO2, and —CN;
- and
- n is selected from 0, 1, 2, and 3.
11 more elements
Dependencies are inferred from the claim text.