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US 10,301,308 B2Granted
Azetidine derivatives for tau imaging
AssigneeEli Lilly and Company
InventorsGiorgio Attardo, Carey Lynn Horchler, Shyamali Ghosh, Hui Xiong
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Abstract
The present invention provides a novel compound of the formula: methods of making this compound, methods of using this compound for tau imaging, and preparations of tau imaging formulations.
Claims9
A compound of the formula selected from the group consisting of:
- or pharmaceutically acceptable salt thereof.
A compound of the formula selected from the group consisting of:
A process of making a compound of the formula:
- comprising reacting a compound of the formula selected from the group consisting of:
- with a source of [18F]fluoride.
A composition comprising a compound of the formula selected from the group consisting of
- or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
A composition comprising
- and 10% EtOH (v/v), 0.45% (w/v) sodium ascorbate in 0.9% sodium chloride.
A method of imaging aggregated tau comprising:
- a. introducing into a mammal a detectable quantity of the compound:
- or a pharmaceutically acceptable salt thereof,
- b. allowing sufficient time for said compound to become associated with tau;
- and
- c. detecting said compound.
2 more elements
Dependencies are inferred from the claim text.