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US 10,300,471 B2Granted
Ruthenium-catalyzed synthesis of biaryl compounds in water
OwnerAli Aiden Koohang, Anita Mehtainventors
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Abstract
Using a [RuCl2(arene)]2 complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl2(arene)]2 and a formate source may be prepared in situ or isolated for later use.
Claims2
A ruthenium catalyst prepared by
- reacting one part of [RuCl2(p-cymene)]2 with our parts of sodium formate in dichloromethane to produce a ruthenium catalyst product;
- precipitating or crystallizing the ruthenium catalyst product with hexanes;
- and
- washing the ruthenium catalyst product with ethyl acetate.
1 more element
Dependencies are inferred from the claim text.