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US 10,300,245 B2Granted
Therapeutic agent applicators and methods of using the same
AssigneesH. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
InventorsSteven E. Finkelstein, Matthew C. Biagioli, Mayer N. Fishman
Life of this patent
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Abstract
The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic agents to cancerous tissue located in a subject.
Claims28
A device for treatment of cancerous tissue, comprising:
- an applicator with a first elongate portion and a second elongate portion, each elongate portion terminating in a rigid distal end and each elongate portion defining a lumen, the distal end of the first elongate portion having sufficient rigidity to advance within the cancerous tissue without additional support;
- wherein the distal end of the first elongate portion is closed, thereby blocking its lumen, and wherein the first elongate portion is configured to direct passage of a therapeutic agent towards the distal end, wherein the first elongate portion further comprises at least one opening spaced from the closed distal end and in communication with the lumen of the first elongate portion, the at least one opening configured for directing the therapeutic agent from the lumen of the first elongate portion to the cancerous tissue;
- wherein the distal end of the second elongate portion is closed, thereby blocking its lumen, and wherein the second elongate portion is configured for directing a brachytherapy seed into proximity to the cancerous tissue, wherein the lumen of the first elongate portion and the lumen of the second elongate portion are not in fluid communication with each other;
- wherein each elongate portion has a longitudinal axis and wherein the second elongate portion is positioned within the lumen of the first elongate portion such that:
- (a) the longitudinal axes of the first and second lumens are substantially aligned;
- (b) the closed distal end of the first elongate portion prevents distal advancement of the second elongate portion beyond its distal end;
- (c) the distal end of the second elongate portion is proximal in relation to the longitudinal axis as compared to the distal end of the first elongate portion;
- and
- wherein the applicator comprising the first elongate portion and the second elongate portion are configured for simultaneous placement in, or in proximity to, the cancerous tissue.
6 more elements
Dependencies are inferred from the claim text.