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US 10,300,176 B2Granted
Catheter lock solution formulations
AssigneeMedline Industries, Inc.
InventorsLecon Woo, William Anderson
Life of this patent
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Abstract
A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial.
Claims12
A catheter locking method comprising:
- introducing a locking composition into a lumen of the implantable catheter, wherein the locking composition comprises:
- a lower alcohol comprising ethanol;
- sodium citrate;
- and
- a liquid excipient comprising one or more of glycerol and polysorbate-20, wherein the liquid excipient is present in an amount less than the amount of sodium citrate and at a sufficient concentration to inhibit crystallization of sodium citrate.
2 more elements
Dependencies are inferred from the claim text.