Compounds and methods for biofilm disruption and prevention
AssigneeUniversity of Newcastle Upon Tyne
InventorsJames Grant Burgess, Michael John Hall, Reindert Nijland
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Abstract
The invention relates to compounds, compositions and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.
Claims21
A pharmaceutical or anti-biofouling composition for disrupting a biofilm or preventing biofilm formation comprising an isolated microbial deoxyribonuclease polypeptide and an excipient, wherein said composition is coated on at least a portion of a patient-contactable surface of an indwelling medical device, and wherein the microbial deoxyribonuclease is as set forth in SEQ ID NO. 4.
A method of preventing or disrupting a biofilm on a surface comprising:
- expressing a microbial deoxyribonuclease polypeptide from an expression vector that comprises a polynucleotide encoding the microbial deoxyribonuclease;
- and
- contacting the surface with an effective dose of the microbial deoxyribonuclease polypeptide, wherein the surface is at least a portion of a patient-contactable surface of an indwelling medical device, wherein the microbial deoxyribonuclease is as set forth in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.