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US 10,300,172 B2Granted
Matrix for enhanced delivery of osteoinductive molecules in bone repair
AssigneeBioventus, LLC
InventorsEric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
Life of this patent
Estimating the term…
Abstract
Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
Claims19
A composition, comprising:
- a porous biocompatible polymer matrix having a plurality of macropores having an average size of about 100 μm to about 500 μm;
- admixed with a calcium ceramic granule having an average diameter of about 425 μm to about 800 μm and having an interconnected network of micropores defining at least one surface on an interior of the granule and wherein the calcium ceramic granule has a pH of less than 7, as measured in a slurry of said granules and water or another neutral, non-buffering solution.
A method of treating a patient, comprising the steps of:
- contacting a bony tissue of the patient with a composition, comprising:
- a porous biocompatible matrix, the matrix including a plurality of macropores having an average size of about 100 μm to about 500 μm;
- a calcium ceramic granule contacting the porous biocompatible matrix, said granule having an interconnected network of micropores defining at least one surface on an interior of the granule, wherein said granule has an average diameter of about 425 μm to about 800 μm and a pH of less than 7, as measured in a slurry of said granules and water or another neutral, non-buffering solution;
- and
- an osteoinductive protein associated with the at least one surface on the interior of the granule, wherein the osteoinductive protein is distributed on a portion of the at least one surface near the centroid of the granule and on a portion of the at least one surface near the exterior of the granule.
2 more elements
A kit for treating a patient, comprising:
- a carrier, comprising:
- a porous biocompatible matrix, the matrix including a plurality of macropores having an average size of about 100 μm to about 500 μm;
- and
- a calcium ceramic granule contacting the porous biocompatible matrix, said granule having an interconnected network of micropores defining at least one surface on an interior of the granule, wherein said granule has an average diameter of about 425 μm to about 800 μm and a pH of less than 7, as measured in a slurry of said granules and water or another neutral, non-buffering solution;
- and
- a vessel holding an osteoinductive protein in a form in which the osteoinductive solution can be added to a fluid to form a solution, the solution being adapted to wet the carrier, thereby associating the osteoinductive protein with the at least one surface on the interior of the granule, thereby forming an implant.
3 more elements
Dependencies are inferred from the claim text.