Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation
AssigneeAllergan, Inc.
InventorsXiaojie Yu, Darin J. Messina, Elizabeta Pavlovic, Cunqi Cui, Kate M. Smither
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Abstract
Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.
Claims20
A soft tissue augmentation product comprising:
- a forming component comprising a hydrogel composition and a lipoaspirate;
- wherein the hydrogel composition comprises water and a crosslinked macromolecular matrix, the crosslinked macromolecular matrix comprising:
- a hyaluronic acid component;
- and
- a silk fibroin component;
- wherein the hyaluronic acid component is crosslinked to the silk fibroin component by a multiamine cross linker;
- and
- wherein the soft tissue augmentation product is configured for administration to a soft tissue of a human subject.
A method of augmenting soft tissue of a human being comprising:
- providing a hydrogel composition comprising water and a crosslinked macromolecular matrix, the crosslinked macromolecular matrix comprising a hyaluronic acid component and a silk fibroin component, wherein the hyaluronic acid component is crosslinked to the silk fibroin component by a multiamine cross linker;
- and
- mixing the hydrogel composition with an ex vivo lipoaspirate to produce a hydrogel lipoaspirate mixture.
The method of 7, wherein the crosslinked macromolecular matrix has a weight ratio of the hyaluronic acid component to the silk fibroin component in the range of 25:1 to 1:1.
A method of grafting fat in a human subject, the method comprising providing a composition, wherein the composition comprises:
- (i) a hydrogel comprising:
- water and a crosslinked macromolecular matrix, the crosslinked macromolecular matrix comprising a hyaluronic acid component and a silk fibroin component, wherein the hyaluronic acid component is crosslinked to the silk fibroin component by a multiamine cross linker;
- and
- (ii) a fat component, comprising a lipoaspirate.
Dependencies are inferred from the claim text.