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US 10,300,156 B2Granted
Radiotracer compositions and methods
AssigneeGe Healthcare Limited
InventorsTorgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Robert James Nairne, Graeme McRobbie
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Abstract
The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
Claims2
A radiopharmaceutical composition which comprises:
- (i) a radiotracer that has a radioactive concentration of 500-700 MBq/mL of Formula (II):
- (ii) a radioprotectant which comprises 4-aminobenzoic acid, or a salt thereof with a biocompatible cation;
- (iii) a biocompatible carrier which comprises aqueous ethanol having an ethanol content of 0.1 to 10% v/v;
- in a form suitable for mammalian administration, where at least 90% of the 18F radioactive content is the radiotracer of Formula (II), and less than 10% of said content is the total of [18F]-4-fluorobenzaldehyde and [18F]-4-fluorobenzonitrile
- wherein Ca, Cb, Cc, and Cd are each cysteine residues such that residues Ca and Cb as well as Cc and Cd are cyclized to form two separate disulfide bonds.
2 more elements
Dependencies are inferred from the claim text.