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US 10,300,155 B2Granted
Alpha-synuclein ligands
AssigneeWashington University
InventorsZhude Tu, Junfeng Li, Xuyi Yue, Paul Kotzbauer
Life of this patent
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Abstract
The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).
Claims20
A compound having the structure of Formula (III-A):
- wherein A11 is C—R11 or nitrogen;
- A12 is C—R12 or nitrogen;
- A13 is C—R13 or nitrogen;
- A14 is C—R14;
- A15 is C—R15 or nitrogen and at least one of A11, A12, A13, or A15 is nitrogen;
- R11, R12, R13, R15, R16, R17, R18, R20, and R21 are independently hydrogen, nitro, halo, hydroxy, carboxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted carboxylate, substituted or unsubstituted amino, or substituted or unsubstituted amido;
- R14 is nitro, halo, hydroxy, carboxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted carboxylate, substituted or unsubstituted amino, or substituted or unsubstituted amido;
- and
- R19 is nitro, halo, hydroxy, carboxyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted carboxylate, substituted or unsubstituted amino, or substituted or unsubstituted amido, and
- wherein the compound is radiolabeled with a synthetic radioactive isotope.
7 more elements
A compound selected from the group consisting of:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.