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US 10,300,154 B2Granted
Anticoagulant derivatives for cardiovascular imaging
OwnerDavid R Elmalehinventor
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Abstract
The invention provides cardiovascular imaging agents comprising an anticoagulant (e.g., dabigatran derivatives) with a label (e.g., radiolabeled, fluorinated or radiofluorinated). Methods for using the cardiovascular imaging agents and kits containing the cardiovascular imaging agents or components suitable for production of the cardiovascular imaging agents are also provided.
Claims13
A dabigatran DTI derivative or a product of dabigatran DTI derivative with a PET or SPECT radiolabel, represented by structure (A):
- wherein R is H, Et, Me, or Bu;
- R2 is H, Et, Me, or Bu;
- n is a number from 2 to 6;
- m is a number from 2 to 6;
- Z is alkyl, substituted alkyl, alkylene, aryl, or halogen;
- Y is alkyl, substituted alkyl, alkylene, aryl, or halogen;
- and
- X is halogen, radiohalogen, chelating moiety or radiolabeled chelating moiety.
5 more elements
Dependencies are inferred from the claim text.