Virion-derived nanospheres for selective delivery of therapeutic and diagnostic agents to cancer cells
AssigneeAura Biosciences, Inc.
InventorsElisabet de los Pinos, Rhonda C. Kines
Life of this patent
Estimating the term…
Abstract
The invention relates to methods for producing papilloma-derived nanosphere particles that contain therapeutic, diagnostic, or other agents. The invention also provides nanosphere particle preparations that are useful for selectively delivering therapeutic, diagnostic, and/or other agents to cancer cells of subjects without eliciting a serotype-specific immunogenic response in the subjects.
Claims31
A nanosphere particle comprising:
- papillomavirus L1 capsid proteins encoded by the nucleic acid sequence of SEQ ID NO:
- 2;
- and
- a therapeutic agent attached to a surface of the nanosphere particle.
A nanosphere particle comprising:
- a papillomavirus L1 capsid protein encoded by the nucleic acid sequence of SEQ ID NO:
- 2;
- papillomavirus L2 capsid proteins;
- and
- a dye attached to a surface of the nanosphere particle.
A method comprising expressing in mammalian cells a nucleic acid comprising the sequence of SEQ ID NO:
- 2, and isolating from the mammalian cells L1 capsid protein encoded by the nucleic acid.
A cultured mammalian cell comprising a nucleic acid comprising the sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.