Compositions and methods for induction of TH17 cells
AssigneesRiken, The University of Tokyo, School Corporation, Azabu Veterinary Medicine Educational Institution
InventorsKenya Honda, Koji Atarashi, Masahira Hattori, Hidetoshi Morita
Life of this patent
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Abstract
Strains of human-derived bacteria have been obtained from complex fecal samples and shown to induce accumulation of Th17 cells in the intestine and promote immune functions. Pharmaceutical compositions containing these bacteria can be used as anti-infectives and as adjuvants in mucosal vaccines.
Claims14
A composition that induces proliferation and/or accumulation of Th17 cells, the composition comprising, as an active component three or more bacteria selected from the group consisting of:
- Clostridium symbiosum, Clostridium hathewayi, Clostridium citroniae, Clostridium bolteae, Ruminococcus sp. M-1, Ruminococcus gnavus, Blautia sp. canine oral taxon 143, Anaerostipes caccae, Clostridium lactatifermentans, Coprobacillus cateniformis, Clostridium ramosum, cf. Clostridium sp. MLG055, Clostridium innocuum, Eubacterium desmolans, Clostridium orbiscindens, Ruminococcus sp. 16442, Anaerotruncus colihominis, Bacteroides dorei, Bifidobacterium pseudolongum subsp. Pseudolongum, and Bifidobacterium breve;
- and one or more enteric polymers.
A composition that induces proliferation and/or accumulation of Th17 cells, the composition comprising, as an active component:
- (a) three or more bacteria that contain DNA comprising a nucleotide sequence that has at least 97% homology with a DNA sequence designated herein as SEQ ID Nos. 1-20, or (b) three or more bacteria that contain DNA comprising a nucleotide sequence that has at least 97% homology with DNA of the following bacteria:
- Clostridium symbiosum, Clostridium hathewayi, Clostridium citroniae, Clostridium bolteae, Ruminococcus sp. M-1, Ruminococcus gnavus, Blautia sp. canine oral taxon 143, Anaerostipes caccae, Clostridium lactatifermentans, Coprobacillus cateniformis, Clostridium ramosum, cf. Clostridium sp. MLG055, Clostridium innocuum, Eubacterium desmolans, Clostridium orbiscindens, Ruminococcus sp. 16442, Anaerotruncus colihominis, Bacteroides dorei, Bifidobacterium pseudolongum subsp. Pseudolongum, or Bifidobacterium breve;
- and one or more enteric polymers.
Dependencies are inferred from the claim text.