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US 10,300,134 B1Granted
Vaccine formulations and methods of preparation and use thereof
AssigneeTejas Discovery and Research, LLC
InventorsClaudia Briell, William C. Campaigne, Jeff Nelson
Life of this patent
Estimating the term…
Abstract
A veterinary vaccine composition may include a pharmaceutically acceptable carrier, a biocompatible polymer; and inactive rattlesnake venom. Embodiments may also relate to methods of triggering an immune response in an animal by administering a vaccine composition (containing inactive rattlesnake venom) to the animal and/or methods of formulating a vaccine composition.
Claims15
A veterinary vaccine composition, comprising:
- a pharmaceutically acceptable carrier,
- a biocompatible polymer comprising chitosan;
- and
- a thermally inactivated rattlesnake venom, wherein the thermally inactivated rattlesnake venom is present in in the composition at a concentration ranging from about 1 to 10 mg/mL.
1 more element
A method of triggering an immune response in an animal, comprising:
- administering a vaccine composition to the animal, the vaccine composition comprising a thermally inactivated rattlesnake venom, a biocompatible polymer comprising chitosan, and a pharmaceutically acceptable carrier, wherein the thermally inactivated rattlesnake venom is present in in the composition at a concentration ranging from about 1 to 10 mg/mL.
A method of formulating a vaccine composition, comprising:
- rehydrating a mixture of lyophilized antigen, linear chitosan, and a crosslinking agent, and
- crosslinking the chitosan upon rehydration,
- wherein the antigen is a rattlesnake venom and the method further comprises thermally inactivating the rattlesnake venom prior to lyophilization, wherein the thermally inactivated rattlesnake venom is present in in the composition at a concentration ranging from about 1 to 10 mg/mL.
Dependencies are inferred from the claim text.