US 10,300,133 B2Granted

Compositions for delivery of food allergens to the stomach

AssigneeDBV Technologies

InventorsPierre-Henri Benhamou, Christophe Dupont, Stefan (Johan) Koppelman, Laurent Martin, Hervé Brochard, Estelle Foucher

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Abstract

The invention relates to novel compositions and methods for diagnosing or treating food allergies. The invention particularly discloses new approaches for delivering food allergens to allergic patients by oral administration of formulations which dissolve and release proteins in the stomach. The invention allows the treatment of food allergies by delivering food allergens to the gut immune system with controlled exposure of the esophagus or oral cavity. The invention also allows to perform food challenges to assess the threshold of clinical reactivity without exposing the esophagus and oral cavity. The invention may be used in any subject, particularly human subjects, and is applicable to any food allergen.

Claims18

Dependent claims

A pharmaceutical product suitable for oral administration of a peanut allergen, the pharmaceutical product comprising particles, said particles having a size or average size between 1 μm and 10 mm,

said particles comprising a neutral core surrounded by a first layer comprising heat treated peanut allergen, wherein said neutral core has a diameter of about 90-1000 μm and comprises a polyhydroxylated compound or a sugar, and
said particles further comprise a stomach-labile coating layer stable at neutral pH, said coating layer surrounding said first layer and said coating layer comprising cationic copolymers based on dimethylaminoethyl methacrylate, butyl methacrylate, methyl methacrylate or mixtures thereof,
and wherein the product releases essentially all the heat treated peanut allergen in the stomach.

Dependencies are inferred from the claim text.

Facts

Application: 15/423,820Filed 3 Feb 2017 · continuation in part
Priority: EP 141797114 Aug 2014
Published: US 2017/0151325 A11 Jun 2017
Granted: 28 May 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 39/35
Medicinal preparations containing antigens or antibodies: allergens
A61K 9/50
Preparations in capsules, e.g. of gelatin, of chocolate: microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets…
A61P 37/00
Drugs for immunological or allergic disorders
A61P 37/02
Drugs for immunological or allergic disorders: immunomodulators