Immune complex
AssigneeThe Rockefeller University
InventorsJeffrey V. Ravetch, Taia Wang, Jad Mamaary
Life of this patent
Estimating the term…
Abstract
The present invention relates to immunogenic immune complexes, related compositions, and related methods. This invention addresses the above-described un-met need by providing an immune complex (IC) or immune complexes (ICs), which take advantages of Type II Fc receptor (FcR) interactions and signaling to elicit broader and more potent protective immune responses. In one aspect, the invention provides an immune complex comprising an antigenic agent and an isolated protein. The protein comprises an IgG Fc region and is capable of binding to a Type II Fc receptor. Preferably, the protein is an antibody or an Fc region-containing fragment thereof.
Claims19
An immune complex comprising an antigenic agent and an isolated protein, wherein the antigenic agent comprises an antigen, an epitope, or an immunogenic moiety selected from the group consisting of prion, bacterial, or parasitic antigens, inactivated viral, tumor-derived, protozoal, organism-derived, fungal, or bacterial antigens, toxoids and toxins, wherein the protein comprises an IgG Fc region, and is capable of binding to a Type II Fc receptor, and is a FA241 mutant, and wherein the protein specifically binds to the antigenic agent or conjugated to the antigenic agent.
Dependencies are inferred from the claim text.