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US 10,300,124 B2Granted
Rodent hepadnavirus cores with reduced carrier-specific antigenicity
AssigneeVLP Biotech, Inc.
InventorsDavid R. Milich, David C. Whitacre
Life of this patent
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Abstract
The present disclosure generally relates to hepadnavirus core antigens in which one or more endogenous b cell epitopes have been effectively removed. More specifically, the present disclosure relates to rodent hepadnavirus cores modified to diminish the antibody response to the core so as to enhance the antibody response to heterologous polypeptides included therein.
Claims17
An antigenic composition comprising a hybrid woodchuck hepadnavirus core antigen, wherein
- the hybrid core antigen is a fusion protein comprising a heterologous antigen and a woodchuck hepadnavirus core antigen comprising the amino acid sequence of SEQ ID NO:12 with a serine at position 61, and
- the fusion protein is capable of assembling as a hybrid virus-like particle (VLP).
Dependencies are inferred from the claim text.