Immunogenic compositions for the prevention and treatment of meningococcal disease
AssigneeWyeth Holdings Corporation
InventorsGary W. Zlotnick, Leah Diane Fletcher, John Erwin Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
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Abstract
The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
Claims11
A method of inducing a serum bactericidal antibody response against serogroup B Neisseria meningitidis subfamily B strains in a mammal comprising administering to said mammal a composition comprising an immunologically effective amount of a purified polypeptide consisting of the amino acid sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.