Early cancer detection and enhanced immunotherapy
OwnerGholam A. Peymaninventor
Life of this patent
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Abstract
A method of therapy for a tumor or other pathology by administering a combination of thermotherapy, immunotherapy, and vaccination optionally combined with gene delivery. The combination therapy beneficially treats the tumor and prevents tumor recurrence, either locally or at a different site, by boosting the patient's immune response both at the time or original therapy and/or for later therapy. With respect to gene delivery, the inventive method may be used in cancer therapy, but is not limited to such use; it will be appreciated that the inventive method may be used for gene delivery in general. The controlled and precise application of thermal energy enhances gene transfer to any cell, whether the cell is a neoplastic cell, a pre-neoplastic cell, or a normal cell.
Claims16
A cancer therapeutic method comprising administering to a patient having a tumor a combination of thermotherapy and immunotherapy, where
- thermotherapy comprises systemically administering a plurality of tumor-antibody-coated nanoparticles coated with a thermosensitive polymer, the thermotherapy further comprises heating the tumor-antibody-coated nanoparticles using an energy source at the site of the tumor so as to damage one or more tumor cell membranes and release antigenic material in vivo that activates and stimulates an immunogenic response of the patient at the site of the tumor;
- and
- immunotherapy comprises systemically administering the patient's natural killer (NK) cells/dendritic cells pre-sensitized in vitro to the tumor, and further administering tumor-antibody-coated nanoparticles conjugated with viral-like particles (VLP) while simultaneously administering tumor-antibody-coated nanoparticles conjugated with at least one of checkpoint inhibitors, Rock inhibitors, or Wnt inhibitors to prevent the proliferation of tumor cells or metastatic cells, and/or prevent the tumor cells or metastatic cells from being disguised from T-lymphocytes of the patient or the patient's natural killer (NK) cells.
A cancer therapeutic method comprising administering to a patient having a tumor a combination of thermotherapy and immunotherapy, where
- thermotherapy comprises systemically administering a plurality of tumor-antibody-coated nanoparticles coated with a thermosensitive polymer, the thermotherapy further comprises heating the tumor-antibody-coated nanoparticles using an energy source at the site of the tumor so as to damage one or more tumor cell membranes and release antigenic material in vivo that activates and stimulates an immunogenic response of the patient at the site of the tumor;
- immunotherapy comprises systemically administering the patient's natural killer (NK) cells/dendritic cells pre-sensitized in vitro to the tumor;
- and
- the method further comprises performing precision nanoparticle assisted thermotherapy and generating a photoacoustic image of the cells to which the tumor-antibody-coated nanoparticles bind at an early cellular stage of the tumor, the tumor having a size between one and two millimeters in diameter not easily detectable by radiographic imaging.
Dependencies are inferred from the claim text.