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US 10,300,114 B2Granted
Bioerodible sustained release drug delivery systems
AssigneeEyePoint Pharmaceuticals US, Inc.
InventorsHong Guo, Jianbing Chen, Dongling Su, Paul Ashton
Life of this patent
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Abstract
The present invention relates to sustained release drug delivery systems, medical devices incorporating said systems, and methods of use and manufacture thereof. The inventive systems feature bioerodible drug delivery devices that include biocompatible solid and biocompatible fluid compositions to achieve desired sustained release drug delivery.
Claims28
A drug delivery system comprising:
- an inner core, comprising
- (i) a biocompatible fluid component,
- (ii) a biocompatible solid component, wherein said biocompatible solid component comprises a bioerodible polymer, and said biocompatible solid component is dissolved, suspended, or dispersed in the biocompatible fluid component, and
- (iii) at least one agent dispersed, suspended, or dissolved within the inner core, wherein the at least one agent comprises a peptide or protein and has the structure
- A(-L-)mSn
- wherein A is a residue of the peptide or protein, m and n are independently integers in the range of 1-4;
- L is a covalent bond or a linker moiety, and S is a polyoxyethylene ether group having the formula —(OCH2CH2)pOR, where p is in the range of 2-12 and R is a C1-C4 alkyl group;
- wherein the inner core is a viscous paste or a gel;
- a first polymer layer, impermeable to the passage of the at least one agent, that covers at least part of but less than 100% of said inner core;
- and
- a second polymer layer, permeable to the passage of the at least one agent, wherein the permeability of the second polymer layer to the passage of the at least one agent permits the at least one agent to diffuse from the inner core when the drug delivery system is surrounded by a physiological fluid.
8 more elements
A method of manufacturing a drug delivery system, comprising:
- providing an inner core, said inner core comprising
- (i) a biocompatible fluid component;
- (ii) a biocompatible solid component, wherein said biocompatible solid component comprises a bioerodible polymer, and said biocompatible solid component is dissolved, suspended, or dispersed in the biocompatible fluid component,
- (iii) at least one agent dispersed within said inner core, wherein the at least one agent comprises a peptide or protein and has the structure
- A(-L-)mSn
- wherein A is a residue of the peptide or protein, m and n are independently integers in the range of 1-4;
- L is a covalent bond or a linker moiety, and S is a polyoxyethylene ether group having the formula —(OCH2CH2)pOR, where p is in the range of 2-12 and R is a C1-C4 alkyl group;
- wherein the inner core is a viscous paste or a gel;
- combining said inner core with a first polymer layer that is impermeable to the at least one agent and covers at least part of but less than 100% of said inner core;
- and
- adding a second polymer layer that is permeable to the passage of the at least one agent, wherein the permeability of the second polymer layer to the passage of the at least one agent permits the at least one agent to diffuse from the inner core when the drug delivery system is surrounded by a physiological fluid.
8 more elements
Dependencies are inferred from the claim text.