Methods of treating obesity by administering a TAT peptide
OwnerMan-Wook Hur, Jae-Eun Kang +2inventors
InventorsMan-Wook Hur, Jae-Eun Kang, Min-Seon Kim, Kyung-Sup Kim
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Abstract
The present invention relates to a composition for preventing, alleviating or treating obesity comprising a partial fragment of HIV-1 (Human Immunodeficiency Virus-1) Tat (Trans activator of transcription) protein. The peptides of the present invention induce anorexia and increase lipolysis, β-oxidation of free fatty acids, thermogenesis, and total energy expenditure, therefore may be effectively used for preventing or treating diseases related to metabolic imbalance such as obesity.
Claims9
A method of alleviating or treating obesity in a subject in need thereof, the method comprising administering to the subject a composition comprising at least one of the group consisting of a peptide consisting of the amino acid sequence of SEQ ID NO:
- 1 and a peptide consisting of the amino acid sequence of SEQ ID NO:2, wherein after administration of the composition, the subject's obesity is alleviated or treated.
A method of reducing adipose tissue in a subject in need thereof, the method comprising administering to the subject a composition comprising at least one of the group consisting of a peptide consisting of the amino acid sequence of SEQ ID NO:
- 1 and a peptide consisting of the amino acid sequence of SEQ ID NO:2, wherein after administration of the composition, the subject's adipose tissue is reduced.
A method of increasing energy expenditure in a subject in need thereof, the method comprising administering to the subject a composition comprising at least one of the group consisting of a peptide consisting of the amino acid sequence of SEQ ID NO:
- 1 and a peptide consisting of the amino acid sequence of SEQ ID NO:2, wherein after administration of the composition, energy expenditure in the subject is increased.
Dependencies are inferred from the claim text.