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US 10,300,081 B2Granted
Modified release doxycycline composition
AssigneeNestlé Skin Health S.A.
InventorsAnkit Baheti, Bijay Kumar Padhi, Rajeev Singh Raghuvanshi
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Abstract
Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a day and exhibit a reduced food effect. Methods of treating inflammatory conductions such as rosacea or inflammatory symptoms such as the papules and pustules of rosacea or acne vulgaris are also disclosed.
Claims9
A modified release oral composition comprising:
- i. about 30 to less than about 50 mg of doxycycline, based on the equivalent weight of doxycycline base;
- ii. one or more water soluble and insoluble polymers;
- and
- iii. one or more pharmaceutically acceptable excipients;
- wherein said composition is free of any immediate release component;
- wherein the doxycycline is in an amount of about 15-20% w/w, the water soluble and insoluble polymers are in an amount of about 10-18% w/w, and the pharmaceutically acceptable excipients are in an amount of about 1-20% w/w, based on the total weight of the composition;
- and
- wherein said composition has dC/dT value of less than about 80% of the dC/dT value provided by the commercially available 40 mg doxycycline composition, measured in a single dose human pharmacokinetic study in a fasting state and in a time period of T0 min to T60 mins.
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Dependencies are inferred from the claim text.