Methods and compounds to inhibit enveloped virus release
AssigneesNorthwestern University, The Research Foundation for The State University
InventorsJonathan Leis, Carol Carter
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Abstract
A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
Claims7
A method of inhibiting release of an enveloped virus from a cell, consisting of contacting the cell with a compound having an antiviral activity, said antiviral activity comprises:
- (i) inhibiting formation of an associative complex;
- or
- (ii) disrupting formation of an associative complex,
- wherein the associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus,
- wherein the enveloped virus is selected from the group consisting of Lassa fever virus, lymphocytic choriomeningitis virus, Ebola virus, Marberg virus, hepatitis B virus, Herpes simplex virus, type 1, Herpes simplex virus, type 2, cytomegalovirus, Simian virus, type 5, Mumps virus, avian sarcoma leucosis virus, human immunodeficiency virus, type 1, human T-lymphotrophic virus, type 1, equine infectious anemia virus, vesicular stomatitis virus, rabies virus and combinations thereof,
- wherein the compound is formula (VIII):
Dependencies are inferred from the claim text.