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US 10,300,075 B2Granted
Compounds that inhibit MCL-1 protein
AssigneeAmgen Inc.
InventorsSean P. Brown, Kexue Li, Yunxiao Li, Markian M. Stec
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Abstract
Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.
Claims39
A compound, wherein the compound is selected from:
- or the stereoisomer thereof, the pharmaceutically acceptable salt thereof, or the pharmaceutically acceptable salt of the stereoisomer thereof.
Dependencies are inferred from the claim text.