Use of CDK9 and BRD4 inhibitors to inhibit inflammation
AssigneeThe Regents of the University of California
InventorsDominik Haudenschild, Jasper Yik
Life of this patent
Estimating the term…
Abstract
Provided are methods for the combined use of cyclin-dependent kinase 9 (CDK9) inhibitors and bromodomain containing 4 (BRD4) inhibitors to reduce, inhibit and/or prevent cartilage degradation and systemic traumatic inflammation. A combination of CDK9 inhibitors and BRD4 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. A combination of CDK9 inhibitors and BRD4 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
Claims27
A method of reducing, inhibiting, mitigating and/or ameliorating cartilage degradation and/or chondrocyte death in a subject in need thereof, comprising co-administering to the subject an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9) and an inhibitor of bromodomain containing protein 4 (BRD4), thereby reducing, inhibiting, mitigating and/or ameliorating cartilage degradation and/or chondrocyte death in the subject, wherein the CDK9 inhibitor and the BRD4 inhibitor are initially co-administered within about 10 day after experiencing traumatic injury.
A method of reducing, inhibiting, mitigating and/or ameliorating the onset and/or progression of post-traumatic osteoarthritis in a subject in need thereof, comprising co-administering to the subject an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9) and an inhibitor of bromodomain containing protein 4 (BRD4), thereby reducing, inhibiting, mitigating and/or ameliorating post-traumatic osteoarthritis in the subject, wherein the CDK9 inhibitor and the BRD4 inhibitor are initially co-administered within about 10 days after experiencing traumatic injury.
A method of reducing, inhibiting, mitigating and/or ameliorating severe polytrauma or systemic inflammatory response syndrome (SIRS) in a subject in need thereof, comprising administering to the subject an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9) and an inhibitor of bromodomain containing protein 4 (BRD4), thereby reducing, inhibiting, mitigating and/or ameliorating severe polytrauma or systemic inflammatory response syndrome (SIRS) in the subject, wherein the CDK9 inhibitor and the BRD4 inhibitor are initially co-administered within about 10 days after experiencing traumatic injury.
A method of reducing, inhibiting, mitigating and/or ameliorating severe polytrauma or systemic inflammatory response syndrome (SIRS) in a subject in need thereof, comprising co-administering to the subject an effective amount of an inhibitor of cyclin-dependent kinase 9 (CDK9) and an inhibitor of bromodomain containing protein 4 (BRD4), thereby reducing, inhibiting, mitigating and/or ameliorating severe polytrauma or systemic inflammatory response syndrome (SIRS) in the subject, wherein the CDK9 inhibitor and the BRD4 inhibitor are initially co-administered within about 10 days after experiencing traumatic injury.
A method of reducing, or inhibiting degradation of an osteochondral explant and/or reducing, preventing or inhibiting chondrocyte death during storage, comprising storing the osteochondral explant and/or chondrocytes in a solution comprising an inhibitor of cyclin-dependent kinase 9 (CDK9) and an inhibitor of bromodomain containing protein 4 (BRD4).
A composition comprising an osteochondral explant in a solution comprising an inhibitor of cyclin-dependent kinase 9 (CDK9) and an inhibitor of bromodomain containing protein 4 (BRD4).
Dependencies are inferred from the claim text.