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US 10,300,061 B2Granted
Aminothiazole compounds as protein kinase inhibitors
AssigneeNational Health Research Institutes
InventorsWeir-Torn Jiaang, Chuan Shih, Hui-Jen Tsai
Life of this patent
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Abstract
Aminothiazole compounds of Formula (I) shown below and pharmaceutical compositions containing one of such compounds: Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds.
Claims26
A compound of formula (I) below or a pharmaceutically acceptable salt thereof:
- wherein
- R1 is C1-6 alkyl or C1-6 thioalkyl;
- X is O or NRa, in which Ra is H or C1-6 alkyl;
- Y is CRbRc or NRd, in which each of Rb and Rc, independently, is H, halo, C1-6 alkyl, C1-6 alkoxyl, or amino, or Rb, together with Ra, the carbon atom bonded to Rb, and the nitrogen atom bonded to Ra, is C3-10 heterocycloalkyl;
- and Rd is H or C1-6 alkyl, or Rd, together with Ra and the nitrogen atoms bonded to Rd and Ra, is C3-10 heterocycloalkyl;
- R2 is —CH2CH2Re or NRfRg, in which Re is H, halo, C1-6 alkyl, or ORh and each of Rf and Rg, independently, is C1-6 alkyl or C3-8 cycloalkyl, Rh being H or C1-6 alkyl, or Rh, together with Rd, the oxygen atom bonded to Rh, and the nitrogen atom bonded to Rd, being C3-10 heterocycloalkyl;
- and
- R3 is 6-membered heteroaryl.
5 more elements
Dependencies are inferred from the claim text.