Pharmaceutical composition and therapeutic combination comprising a cholesteryl ester transfer protein inhibitor and HMG CoA reductase inhibitors
AssigneeDezima Pharma B.V.
InventorsJohn Ford, Patrick Round, John Kastelein
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Abstract
The present invention relates to a pharmaceutical composition and a therapeutic combination comprising a novel cholesteryl ester transfer protein (CETP) inhibitor and a HMG CoA Reductase inhibitor, which may be used in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia.
Claims15
A pharmaceutical composition comprising:
- (a) a compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- (b) at least one HMG CoA reductase inhibitor or a pharmaceutically acceptable salt thereof;
- and
- (c) one or more pharmaceutically acceptable excipients;
- wherein the composition comprises 1 mg to 25 mg of Compound A or a pharmaceutically acceptable salt thereof and 1 mg to 80 mg of the HMG CoA reductase inhibitor or a pharmaceutically acceptable salt thereof wherein the composition is formulated as an oral fixed dose combination for a once a day administration.
The pharmaceutical composition according to claim wherein the composition is an oral fixed dose combination comprising 1 mg, 2.5 mg, 5 mg or 10 mg of Compound A and 10 mg to 20 mg of atorvastatin or rosuvastatin.
Dependencies are inferred from the claim text.