Cyclopropylamines as LSD1 inhibitors

A method of treating a disease, wherein said disease is selected from sickle cell disease, leiomyosarcoma, hepatocellular carcinoma, small cell lung cancer, Ewing's sarcoma, neuroblastoma, glioblastoma, breast cancer, prostate cancer, ovarian cancer, acute myelogenous leukemia, and myelofibrosis, comprising administering to a patient a therapeutically effective amount of a compound of Formula IIIa:

• or a pharmaceutically acceptable salt thereof, wherein:
• ring A is phenyl;
• RZ is CN, ORa, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2,3-difluorophenyl, 3,4-difluorophenyl, 4-(cyanomethyl)phenyl, 3-carboxyphenyl, 3-[(3S)-tetrahydrofuran-3-yloxy]phenyl, 3-(tetrahydropyran-4-yloxy)phenyl, 4-cyanophenyl, 4-cyano-2-fluorophenyl, 3-cyanophenyl, 6-methoxypyridin-3-yl, 5-fluoropyridin-2-yl, 4-methoxyphenyl, 3-(aminocarbonyl)phenyl, 3-methoxyphenyl, 3-ethoxyphenyl,
• each R1 is independently selected from halo or C1-6 alkyl;
• RN is H or RB;
• each RB is independently selected from C1-6 alkyl, 4-10 membered heterocycloalkyl, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, and S(O)2Rb2, wherein said C1-6 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from Cy, halo, CN, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, C(═NRe2)NRc2Rd2, NRc2C(═NRe2)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc1Rd2;
• R3 and R4 are each independently selected from H, halo, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, and —(C1-4 alkyl)-ORa4;
• R5 and R6 are each independently selected from H, halo, CN, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, and —(C1-4 alkyl)-ORa4;
• each Cy is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl;
• Ra is selected from C1-6 alkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, C6-10 aryl-C1-4 alkyl-, and C3-10 cycloalkyl-C1-4 alkyl-, each of which is optionally substituted with halo or CN;
• each Ra2, Rb2, Rc2, and Rd2 is independently selected from H, C1-6 alkyl, and Cy, wherein said C1-6 alkyl is optionally substituted with 1 or 2 substituents independently selected from Cy, halo, CN, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)NRc4Rd4, NRc4C(O)ORa4, C(═NRe4)NRc4Rd4, NRc4C(═NRe4)NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, and S(O)2NRc4Rd4;
• or any Rc2 and Rd2 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group;
• each Ra4, Rb4, Rc4, and Rd4 is independently selected from H, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, and C2-4 alkynyl, wherein said C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl, is optionally substituted with 1, or 2 substituents independently selected from OH, CN, amino, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylamino, di(C4 alkyl)amino, C1-4 haloalkyl, and C1-4 haloalkoxy;
• each Re2 and Re4 is independently selected from H, C1-4 alkyl, and CN;
• n is 0, 1, 2, or 3;
• q is 0, 1, or 2;
• and
• s is 1, 2, 3, or 4.