Proteinoid compounds, process of preparing same and uses thereof
AssigneeBar-Ilan University
InventorsShlomo Margel, Michal Kolitz Domb, Stella Kiel, Elisheva Sason
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Abstract
Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed.
Claims19
A proteinoid compound comprising a polymeric backbone, wherein said polymeric backbone comprises monomeric units and polyester, wherein each of said monomeric units being derived from an amino acid, and wherein said polymeric backbone is characterized by a molecular weight (Mw) of at least 15,000 Da.
A process of synthesizing a proteinoid compound characterized by molecular weight (Mw) of at least 15,000 Da, the process comprising:
- a) heating one or more types of amino acid to a temperature that ranges from 100° C. to 200° C., under an inert gas, thereby forming a molten content or a mixture of said one or more amino acids;
- b) stirring said molten content or a mixture at a temperature that ranges from 100° C., to 200° C., for at least 30 min, thereby polymerizing a plurality of monomeric units and polyester, each of said monomeric units being derived from said one or more amino acids in said mixture;
- c) bringing the content or mixture to room temperature;
- d) adding water to said content or a mixture, thereby obtaining a proteinoid compound solution;
- and
- e) cleaning (e.g., dialyzing) said solution to thereby obtain the proteinoid compound.
Dependencies are inferred from the claim text.