Stabilized assembled nanostructures for delivery of encapsulated agents
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJeffrey M. Karp, Nitin Joshi, Nikken Wiradharma, Kai Vincent Slaughter
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Abstract
A non-covalently assembled hydrogel or organo-gel composition with serum stability is described. Low molecular weight (<2,500 Da), generally regarded as safe (GRAS), materials assemble in the presence of a stabilizing agent at an appropriate molar percentage, forming hydrogel or organo-gel with nanostructures that resist disassembly or destabilization in serum for an extended period of time. The composition is used to deliver one or more therapeutic, prophylactic, or diagnostic agents, allowing for controlled release in response to biological stimuli such as enzymes and a greatly improved dosing efficacy.
Claims30
A self-assembled organo or hydrogel composition comprising
- one or more low molecular weight amphiphilic gelators having a molecular weight of less than 2,500 Da and
- one or more stabilizing agents,
- wherein the gelators and the stabilizing agents co-assemble into hydrogel or organo-gel comprising nanostructures, or the gelators assemble into hydrogel or organo-gel comprising nanostructures that encapsulate the stabilizing agents,
- wherein the composition maintains at least 50, 60, 70 or 80% of its size and does not aggregate to twice the size the composition was prior to exposure to serum proteins for at least 30 minutes in the presence of serum proteins in phosphate buffered saline at 37° C.
Dependencies are inferred from the claim text.