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US 10,299,915 B2Granted
Synthetic heart valves composed of zwitterionic polymers
AssigneeBoston Scientific Scimed, Inc.
InventorsPeter G. Edelman, Mark W. Boden, Joseph Thomas Delaney, Jr.
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Abstract
A prosthetic heart valve includes a plurality of synthetic polymeric leaflets. Each leaflet has a base polymer and a polymer coating at least partially disposed over the base polymer, wherein the polymer coating includes polymerized units of a monomer comprising a zwitterionic group when the polymer coating is exposed to an aqueous environment at a pH of about 7.4.
Claims16
A prosthetic heart valve comprising
- a plurality of synthetic polymeric leaflets, each leaflet having a base polymer and a polymer coating disposed over the base polymer,
- wherein the polymer coating comprises a trimethoxysilane functionalized polymer comprising zwitterionic pendant groups, wherein each zwitterionic pendant group comprises an anionic group and a cationic group.
A prosthetic heart valve comprising
- a plurality of synthetic polymeric leaflets, each leaflet having a base polymer and a polymer coating disposed over the base polymer,
- wherein the polymer coating comprises a trimethoxysilane functionalized polymer that is the reaction product of one or more monomers comprising zwitterionic pendant groups and one or more monomers comprising non-zwitterionic pendent groups.
A prosthetic heart valve comprising
- a plurality of synthetic polymeric leaflets, each leaflet having a base polymer and a polymer coating disposed over the base polymer;
- wherein the polymer coating comprises a polymer comprising zwitterionic pendant groups, wherein each zwitterionic pendant group comprises an anionic group and a cationic group;
- and
- wherein the polymer of the polymer coating comprises the reaction product of one or more monomer species having a structure selected from the group consisting of:
1 more element
Dependencies are inferred from the claim text.