Three-dimensional quantitative heart hemodynamics in medical imaging

A method for three-dimensional hemodynamic quantification in a medical system, the method comprising:

• capturing cardiovascular spatial data and flow data of a heart of a patient with a medical scanner of the medical system, the spatial and flow data representing a three-dimensional volume;
• measuring pressure data of the patient with a pressure sensor of the medical system;
• generating a three-dimensional representation of a portion of the heart from the spatial data;
• estimating flow across valves of the heart from the flow data;
• personalizing a lumped-parameter hemodynamics model representing at least the portion of the heart of the patient, the personalizing using the spatial data, the flow across the valves, and the pressure data, wherein personalizing the lumped-parameter hemodynamics model comprises calculating mean arterial pressure from the pressure data, calculating ejection fraction and end-diastolic volume from the spatial data, calculating values for a first sub-set of parameters of the lumped-parameter hemodynamics model from the mean arterial pressure, ejection fraction, and end-diastolic volume, and calibrating a second sub-set of the parameters of the lumped-parameter hemodynamics model with an optimization algorithm;
• quantifying a hemodynamic parameter from computational flow dynamics using the three-dimensional representation and using the lumped-parameter hemodynamics model for a boundary condition, the quantifying providing a three-dimensional distribution of the hemodynamic parameter for the portion of the heart;
• and
• indicating a metric on a display for the patient, the metric being a function of the quantifying of the hemodynamic parameter.