Methods and systems for disrupting calcified walls of biological conduits and calcified lesions therein

A method for softening and/or disrupting calcium deposits within the intimal and medial layers of a wall of a biological lumen, comprising:

• generating a series of circumferentially-delivered, pulsatile low-frequency forces against the conduit or lumen wall, the low-frequency forces sufficient to cause a deflection of the lumen wall and produce low-frequency energy waves within the intimal and medial layers of the lumen wall;
• simultaneously generating a series of circumferentially-delivered, pulsatile high-frequency forces against the conduit or lumen wall, the high-frequency forces sufficient to cause a deflection of the lumen wall and produce high-frequency energy waves within the intimal and medial layers of the lumen wall, thereby creating a combination of low-frequency and high-frequency wall forces;
• producing a resulting combination of low-frequency and high-frequency energy waves within the intimal and medial layers of the lumen wall;
• thereby targeting a combination of low-frequency wall forces, high-frequency wall forces, low frequency energy waves and high-frequency energy waves to the intimal and medial layers of the wall of the lumen;
• wherein the generated low-frequency and high-frequency forces comprise initial magnitudes that are increased at least once;
• and
• softening and/or disrupting the calcium deposits within the intimal and medial layers of the wall of the biological lumen as the generated low-frequency and high-frequency forces are increased.