Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide
AssigneeBecton, Dickinson and Company
InventorsCraig A. Gelfand, Daniel Marchiarullo, Keith Moskowitz
Life of this patent
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Abstract
Disclosed are devices for collecting and stabilizing blood that contain a blood stabilization agent which includes variegin or an analog thereof, a polysulfated disaccharide, or a combination thereof, each in an amount effective to stabilize blood. Methods of making and using the devices, and kits containing the devices, are also provided.
Claims16
A device for collecting and stabilizing platelet function in a collected blood sample, wherein the device has a first end and a second end and at least one interior wall defining a reservoir portion for receiving the blood sample, wherein the reservoir comprises an anti-coagulant and a platelet stabilization agent comprising variegin having an amino acid sequence designated as SEQ ID NO:
- 1, or a fragment thereof, wherein the fragment is selected from the group consisting of SEQ ID NOS:
- 2-5 and analogs of such fragments, the analog fragments selected from the group consisting of SEQ ID NOS:
- 6-16, either alone or in combination with a polysulfated disaccharide each in an amount effective to stabilize platelets in the blood collected by the device for at least about twenty-four hours, wherein the device is sterile, at least partially evacuated and which further comprises a closure pierceable by a needle.
Dependencies are inferred from the claim text.