Systems, components, devices and methods for cardiac mapping using numerical reconstruction of cardiac action potentials
AssigneeEp Solutions SA
InventorsAlexander Kalinin, Vitaly Kalinin, Mikhail Tsiklauri, Walther Schulze
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Abstract
Disclosed are various embodiments of invasive and non-invasive systems for electrophysiological mapping of a patient's heart, where cardiac action potentials (APs) on a myocardial surface of a human heart are reconstructed. In one embodiment, the APs are reconstructed using known electrical potentials on the myocardial surface in combination with known geometries of the heart and/or the torso. A mathematical model of cardiac electrical activity may be employed that takes into account homogeneous and isotropic intracellular, extracellular, and human body electrical conductivities.
Claims24
An electrophysiological mapping system (EMS) configured to reconstruct myocardial surface action potentials (APs) corresponding to a patient's heart, comprising:
- (a) a plurality of electrical sensing electrodes configured to acquire cardiac electrical signals from at least portions of at least one of the patient's torso and the patient's heart;
- (b) a data acquisition device operably connected to the electrical sensing electrodes and configured to condition the cardiac electrical signals provided thereby;
- (c) an imaging system configured to generate patient geometry data, and
- (d) at least one non-transitory computer readable medium storing instructions executable by at least one processor configured to perform a method for receiving and processing the cardiac electrical signals and the patient geometry data to reconstruct the APs on a myocardial surface associated with the patient's heart, wherein the method comprises:
- (i) calculating a geometric model of at least one of portions of the patient's torso and portions of the patient's heart;
- (ii) assigning electrical conductivity coefficients of at least one the patient's torso and at least portions of the patient's myocardium to the calculated geometric model;
- (iii) using the cardiac electrical signals, the geometric model, and the electrical conductivity coefficients as inputs, calculating reconstructed electrical potential values and co-normal derivative values associated with the myocardial surface;
- (iv) using the reconstructed electrical potential values and co-normal derivative values, calculating harmonic function values in a myocardial domain by numerically solving the Neumann problem for the Laplace equation;
- and (v) using the harmonic function values, the reconstructed electrical potential values, and the electrical conductivity coefficients as inputs, calculating, for at least portions of the myocardial surface, reconstructed action potential values representative of the APs.
A non-transitory computer-readable medium comprising instructions which, when executed by a computer system, cause the computer system to carry out a method of reconstructing myocardial surface action potentials (APs) corresponding to a patient's heart including the following steps:
- (a) acquiring a plurality of cardiac electrical signals from at least portions of at least one of the patient's torso and the patient's heart;
- (b) acquiring patient geometry data from the patient;
- (c) calculating a geometric model of at least one of portions of the patient's torso and portions of the patient's heart;
- (d) assigning electrical conductivity coefficients of at least one of the patient's torso and at least portions of the patient's myocardium to the calculated geometric model;
- (e) using the cardiac electrical signals, the geometric model, and the electrical conductivity coefficients as inputs, calculating reconstructed electrical potential values and co-normal derivative values associated with the myocardial surface;
- (f) using the reconstructed electrical potential values and co-normal derivative values, calculating harmonic function values in a myocardial domain by numerically solving the Neumann problem for the Laplace equation, and
- (g) using the harmonic function values, the reconstructed electrical potential values, and the electrical conductivity coefficients as inputs, calculating, for at least portions of the myocardial surface, reconstructed action potential values representative of the APs.
Dependencies are inferred from the claim text.