Animal model for type 2 diabetes and obesity

A method of modelling obesity or an obesity-related disorder selected from among insulin resistance and type 2 diabetes, wherein said method comprises the steps of:

• (a) providing a genetically modified mouse whose genome comprises a disruption in the endogenous gene encoding Lysine-specific Demethylase 1 (LSD1), wherein said disruption is a heterozygous deletion of said endogenous LSD1 gene, further wherein the presence of said disruption results in reduced expression of endogenous LSD1 and a corresponding reduced amount of the LSD1 gene-product in at least one tissue or at least one cell type of said mouse;
• and
• (b) feeding said genetically modified mouse a high fat diet until it develops one or more symptoms of obesity selected from the group consisting of increased weight, increased body fat content, reduced insulin sensitivity, and glucose intolerance.