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US 10,295,719 B2Granted
Cylindrical light diffusing device for use in photoimmunotherapy
AssigneeAspyrian Therapeutics, Inc.
InventorsAndreas Rose, Kyle Johnston, Merrill Biel
Life of this patent
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Abstract
The present invention provides a cylindrical light diffusing device comprising a non-circular core fiber having (i) a fiber core that provides a “top hat” core irradiance distribution; (ii) light blocking means that prevent frontal light emisson from distal end of the non-circular core fiber; and (iii) a light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the fiber core of the light diffusing section along central axis of the fiber core, wherein the light diffusion section emits irradiance in a radially symmetric longitudinally “top hat” diffusing irradiance distribution.
Claims21
A cylindrical light diffusing device comprising a non-circular core fiber having:
- i) a non-circular fiber core that provides a “top hat” core irradiance distribution;
- ii) light blocking means that prevent frontal light emission from distal end of the non-circular core fiber and return the frontal light back into the non-circular core fiber for redistribution and emission by a light diffusing section;
- and
- iii) the light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the non-circular fiber core of the light diffusing section along central axis of the fiber core, wherein interactions among the non-circular fiber core, the light blocking means, and the internal scattering features allow the light diffusion section to (a) provide for a constant mixing of light within the light diffusion section resulting in a redistribution of the light that ensures irradiance in center of the fiber core is replenished;
- and (b) emits irradiance in a radially symmetric longitudinally “top hat” diffusing irradiance distribution.
2 more elements
A cylindrical light diffusing device comprising a non-circular core fiber having:
- i) a fiber core that provides a “top hat” core irradiance distribution;
- ii) light blocking means that prevent frontal light emission from distal end of the non-circular core fiber;
- and
- iii) a light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the non-circular fiber core of the light diffusing section along central axis of the fiber core, wherein:
- a) the light diffusion section emits irradiance in a radially symmetric longitudinally “top hat” diffusing irradiance distribution;
- b) the internal scattering features are pairs of parallel cylinders located at different longitudinal locations along the fiber core of the light diffusing section;
- wherein (i) each cylinder within each pair of the parallel cylinders is located at a predetermined distance from the central axis of the fiber core of the light diffusing section;
- and (ii) each pair of the parallel cylinders is oriented at different angles around the central axis than an adjacent pair of the parallel cylinders.
5 more elements
A cylindrical light diffusing device comprising a non-circular core fiber having:
- i) a non-circular fiber core that provides a “top hat” core irradiance distribution;
- ii) light blocking means that prevent frontal light emission from distal end of the non-circular core fiber and return the frontal light back into the non-circular core fiber for redistribution and emission by a light diffusing section;
- and
- iii) the light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the non-circular fiber core of the light diffusing section along central axis of the fiber core, wherein interactions among the non-circular fiber core, the light blocking means, and the internal scattering features allow the light diffusion section to provide a constant mixing of light within the light diffusion section resulting in a redistribution of the light that ensures irradiance in center of the fiber core is replenished;
- and (b) a “top hat” diffusing irradiance distribution, thereby limiting variation of radially emitted irradiance longitudinally from the light diffusing section to be within +/−15% of the average (“I0”) optical irradiance.
2 more elements
A cylindrical light diffusing device comprising a non-circular core fiber having:
- i) a non-circular fiber core that provides a “top hat” core irradiance distribution;
- ii) light blocking means that prevent frontal light emission from distal end of the non-circular core fiber and return the frontal light back into the non-circular core fiber for redistribution and emission by a light diffusing section;
- iii) the light diffusing section having a diffusing proximal end, a diffusing distal end, and internal scattering features distributed within the non-circular fiber core of the light diffusing section are located longitudinally in a non-uniform spiral manner concentric with central axis of the non-circular fiber core of the light diffusing section, wherein interactions among the non-circular fiber core, the light blocking means, and internal scattering features allow the light diffusion section to (a) provide for a constant mixing of light within the light diffusion section resulting in a redistribution of the light that ensures irradiance in center of the fiber core is replenished;
- and (b) emit irradiance in a radially symmetric longitudinally “top hat” diffusing irradiance distribution;
- and
- iv) a translucent covering over the light diffusion section.
3 more elements
Dependencies are inferred from the claim text.