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US 10,295,549 B2Granted
Diagnostic devices and methods of use
AssigneeDignity Health
InventorJonathan E. Valla
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Abstract
The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platelet samples. In another embodiment, the present invention provides a microfluidic device that selectively captures and analyzes a desired amount of target biological particle.
Claims6
A method of processing a liquid sample from a subject, the method comprising the steps of:
- obtaining a liquid sample from the subject;
- adding a reagent to the liquid sample;
- centrifuging the liquid sample to obtain platelet-rich plasma (PRP) fraction comprising unlysed platelets;
- combining the PRP fraction with a staining solution;
- concentrating the stained PRP fraction comprising unlysed platelets within a device comprising an optical measurement chamber;
- and
- quantifying an amount or activity of a mitochondrial protein within the concentrated PRP fraction comprising unlysed platelets from the subject.
4 more elements
Dependencies are inferred from the claim text.