Mycobacterium tuberculosis proteins
AssigneeOxford Immunotec Limited
InventorsMassimo Amicosante, Ian Durrant, Scott Tasker
Life of this patent
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Abstract
The present invention relates to Mycobacterium tuberculosis (M tuberculosis) proteins and immunologically active fragments (peptides or mimotope peptides) thereof. In particular, the invention relates to a group of M. tuberculosis proteins and peptides thereof that are both highly antigenic and characteristic of clinical strains of M. tuberculosis. Accordingly, the further relates to the use of these M. tuberculosis proteins or peptides in diagnosing, treating or preventing M. tuberculosis complex infection.
Claims38
A method for diagnosing Mycobacterium tuberculosis (M. tuberculosis) complex infection in a subject, comprising detecting in vitro using a sample obtained from the subject, an immune response to an M. tuberculosis protein or antigenic fragment thereof selected from the group consisting of (a) Rv0840c (SEQ ID NO:
- 6) or one or more antigenic fragments thereof;
- (b) TBFG_13463 (SEQ ID NO:
- 1) or one or more antigenic fragments thereof (c) Rv1677 (SEQ ID NO:
- 7) or one or more antigenic fragments thereof (d) Rv3845 (SEQ ID NO:
- 4) or one or more antigenic fragments thereof;
- (e) Rv1495 (SEQ ID NO:
- 5) or one or more antigenic fragments thereof;
- and (f) Mtub2_17866 (SEQ ID NO:
- 2) or one or more antigenic fragments thereof;
- and a combination thereof.
A kit for diagnosing Mycobacterium tuberculosis (M. tuberculosis) complex infection in a subject, comprising one or more antigenic fragments of a pool of protein fragments from a protein fragment library encompassing at least 80% of the sequence of TBFG_13463 (SEQ ID NO:
- 1), Mtub2_17866 (SEQ ID NO:
- 2), Rv3845 (SEQ ID NO:
- 4), Rv1495 (SEQ ID NO:
- 5), Rv0840c (SEQ ID NO:
- 6) or Rv1677 (SEQ ID NO:
- 7).
Dependencies are inferred from the claim text.