Feline bitter taste receptors and methods
AssigneeApplied Food Biotechnology, Inc.
InventorsMichelle M. Sandau, Nancy E. Rawson
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Abstract
A family of novel feline bitter taste receptors, referred to as feline TAS2R (fTAS2R), are disclosed herein. Isolated polynucleotides encoding the novel feline bitter taste receptors and chimeric polypeptides are also disclosed, as are expression vectors and host cells for expression of the novel feline bitter taste receptors. Methods of identifying compounds that bind to the novel feline bitter taste receptors and modulate their activity are disclosed.
Claims14
An isolated feline TAS2R (fTAS2R) receptor polypeptide comprising the amino acid sequence of SEQ ID NO:4, wherein the polypeptide is covalently bound to a label, a solid support, a lipid monolayer, or a heterologous polypeptide.
A method for identifying a compound that interacts with a feline TAS2R receptor polypeptide comprising:
- contacting a feline TAS2R receptor polypeptide comprising the amino acid sequence of SEQ ID NO:4 with a test compound, and
- detecting interaction between the receptor polypeptide and the test compound.
Dependencies are inferred from the claim text.