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US 10,295,528 B2Granted
Method of screening ATP11C or CDC50A inhibitor
AssigneeKyoto University
InventorsShigekazu Nagata, Katsumori Segawa
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Abstract
The present invention relates to a method for screening an inhibitor of ATP11C or CDC50A, comprising determining (a) exposure of phosphatidylserine on cell surface, (b) engulfment of cells by macrophages, or (c) cleavage of ATP11C by caspase. The present invention also relates to a method for inducing engulfment of cells by macrophages, comprising inhibiting ATP11C or CDC50A.
Claims3
A method for screening an inhibitor of ATP11C comprising determining cleavage of ATP11C by a caspase,
- wherein the determining step comprises the steps of:
- (1) treating mammalian cells expressing ATP11C or a membrane fraction thereof with a candidate for said inhibitor, and
- (2) measuring the cleavage of ATP11C by the caspase,
- wherein the candidate is selected as an inhibitor of ATP11C when the cleavage of ATP11C is increased by the treatment with said candidate compared to a control.
1 more element
Dependencies are inferred from the claim text.