Descriptor-based methods of electrochemically measuring an analyte as well as devices, apparatuses and systems incorporating the same

A method of electrochemically measuring an analyte in a fluid sample, the method comprising the steps of:

• applying an electrical test sequence to an electrochemical biosensor, the electrochemical biosensor comprising:
• an electrode system,
• a reagent in electrical communication with the electrode system, and
• a receptacle configured to contact the fluid sample provided to the electrochemical biosensor, with the fluid sample in fluidic contact with the reagent, wherein the electrical test sequence comprises at least one direct current (DC) block, the at least one DC block includes at least one excitation potential pulse and at least one recovery potential pulse, each potential configured to produce response information to the electrical test sequence, and wherein a closed circuit condition of the electrode system is maintained during the at least one DC block;
• measuring the response information from the at least one DC block of the electrical test sequence;
• building descriptors encoding magnitude and shape characteristics of the response information to the electrical test sequence, wherein the descriptors encode transformed slope information and transformed intercept information in the response information for at least one excitation current response or recovery current response;
• determining an effective current using the descriptors;
• and
• determining an analyte concentration of the fluid sample based upon the effective current determined using the descriptors, wherein the analyte concentration is a glucose concentration.