In situ NMR parameter monitoring systems and methods for measuring pH and temperature

A method for measuring a pH of a sample in situ using Nuclear Magnetic Resonance (NMR) spectroscopy, the method comprising:

• providing an in situ NMR pH measurement device, the device comprising:
• (1) a sample housing member configured to house a target sample,
• (2) at least one pH sensor configured to exhibit an NMR spectral change due to a change in pH value of the target sample, and
• (3) a pH sensor containment member having an interior portion, the pH sensor containment member configured to house the at least one pH sensor, wherein at least a portion of the pH sensor containment member comprises one or more pores, wherein the one or more pores are configured to allow bidirectional diffusion of hydronium cations and hydroxide anions while maintaining the at least one pH sensor in the interior portion and while precluding direct interaction of the at least one pH sensor and the target sample;
• adding the target sample to the sample housing member;
• obtaining one or more NMR spectra;
• and determining the pH of at least a portion of the target sample.