Compositions and methods for determining likelihood of an increased susceptibility to contracting Johne's disease
AssigneeWisconsin Alumni Research Foundation
InventorsBrian W. Kirkpatrick, George W. Shook, Michael T. Collins
Life of this patent
Estimating the term…
Abstract
Collections of polynucleotides useful estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis trait. Methods for using the collections to estimate breeding value or predict likelihood of an increased susceptibility to contracting paratuberculosis are also provided. Kits comprising the collection of polynucleotides are also provided.
Claims5
A method of prophylactically treating paratuberculosis in a population of cattle, comprising the steps of:
- 1) genotyping a biological sample obtained from one or more members of the cattle population as SNP UA-IFASA-8974 A/C, wherein one copy of BTA20 comprises a polynucleotide segment consisting of SEQ ID NO:53, and the other copy of BTA20 comprises a polynucleotide segment consisting of SEQ ID NO:53 wherein the 61st (central) nucleotide base (C) is substituted with A;
- and
- 2) selectively breeding together two or more members of the cattle population that were genotyped in step 1 as SNP UA-IFASA 8974 A/C;
- whereby paratuberculosis in the cattle population is prophylactically treated.
Dependencies are inferred from the claim text.