Microorganism for production of chemicals derived from acetyl-CoA
AssigneeMitsui Chemcials Inc.
InventorsAnjali Madhavan, Ryota Fujii, Tomonori Hidesaki, Su Sun Chong
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AssigneeMitsui Chemcials Inc.
InventorsAnjali Madhavan, Ryota Fujii, Tomonori Hidesaki, Su Sun Chong
Estimating the term…
Disclosed is an acetyl-CoA-producing microorganism, which is obtained by imparting malate thiokinase and malyl-CoA lyase enzymatic activities to a microorganism having none of the following (a), (b), (c) or (d), without imparting any of (a), (b), (c) or (d), or, even when one or more of (a), (b), (c) or (d) are imparted, not allowing the functions thereof to be exerted: (a) a carbon dioxide fixation cycle having an enzymatic reaction from malonyl-CoA to malonate semialdehyde or 3-hydroxypropionate, (b) a carbon dioxide fixation cycle having an enzymatic reaction from acetyl-CoA and CO2 to pyruvate, (c) a carbon dioxide fixation cycle having an enzymatic reaction from crotonyl-CoA and CO2 to ethylmalonyl-CoA or glutaconyl-CoA or (d) a carbon dioxide fixation cycle having an enzymatic reaction from CO2 to formate.
An acetyl-CoA-producing microorganism of the genus Pantoea in which malate thiokinase and malyl-CoA lyase enzymatic activities are imparted to the microorganism by a gene recombination technology comprising introducing genes encoding said malate thiokinase and malyl-CoA lyase into said microorganism, and wherein said microorganism has none of the following cycles of (a), (b), (c), and (d) and without imparting any of (a), (b), (c), and (d):
Dependencies are inferred from the claim text.