Recombinant microorganisms capable of carbon fixation
AssigneeYeda Research and Development Co. Ltd.
InventorsRon Milo, Niv Antonovsky, Elad Noor, Arren Bar-Even, Yehudit Zohar, Lior Zelcbuch, Shmuel Gleizer, Shira Amram
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Abstract
A microorganism which is genetically modified so that it produces a first essential biomass precursor by metabolizing CO2 using a recombinant carbon fixation enzyme is disclosed. The microorganism produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2. The microorganism does not use the organic carbon source for producing the first essential biomass precursor.
Claims16
An E. coli which is genetically modified to express phosphoribulokinase (prk) and Ribulose-Bisphosphate Carboxylase (RuBisCo), wherein said E. coli produces a first essential biomass precursor by metabolizing CO2, wherein the E. coli produces a second biomass precursor by metabolizing an organic carbon source and not by metabolizing CO2, wherein the E. coli does not use said organic carbon source for producing said first essential biomass precursor, wherein said E. Coli is further modified so as to down-regulate expression or activity of phosphoglycerate mutase (gpm).
A genetically modified E. Coli which expresses a recombinant phosphoribulokinase (prk) and Ribulose-Bisphosphate Carboxylase (RuBisCo) wherein the genes zwf is knocked-out or downregulated.
Dependencies are inferred from the claim text.