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US 10,294,480 B2Granted
Foreign DNA surveillance protein
AssigneePresident and Fellows of Harvard College
InventorsDavid M. Knipe, Megan Horn Orzalli
Life of this patent
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Abstract
A method for augmenting expression of a heterologous nucleic acid in a eukaryotic cell or increasing the efficiency of gene expression using any gene expression system is carried out by decreasing expression or activity of an endogenous Interferon-induced protein-16 (IFI16).
Claims24
A method of augmenting expression of a heterologous nucleic acid in a eukaryotic cell comprising:
- (a) decreasing expression or activity of endogenous Interferon-induced protein-16 (IFI16) in the cell;
- and
- (b) expressing a heterologous nucleic acid in the cell of step (a), wherein said heterologous nucleic acid comprises a viral vector comprising a non-viral or viral coding sequence;
- wherein the steps of (a) and (b) do not occur at the same time.
1 more element
Dependencies are inferred from the claim text.