Aptamer modulators of estrogen receptors
AssigneeThe Research Foundation for The State University of New York
InventorsHua Shi, Daiying Xu, Vamsee Krishna Chatakonda
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Abstract
The present invention relates to a nucleic acid aptamer molecule that includes a domain that binds to an estrogen receptor, molecular complexes that include the nucleic acid aptamer molecule and an estrogen receptor, and constructed DMA molecules and expression systems, as well as host cells, that the contain an RNA aptamer molecule of the invention. Use of these aptamers and encoding constructs to inhibiting estrogen receptor activity in a cell and to treat estrogen receptor-positive cancers is also described.
Claims15
A nucleic acid aptamer molecule comprising a domain that binds to an estrogen receptor, wherein the nucleic acid aptamer molecule comprises a nucleotide sequence according to one of SEQ ID NOS:
- 1-4, 11, 12, 15-18, or minimal effective ER-binding fragments thereof.
Dependencies are inferred from the claim text.